饭局的诱惑

A |     Dhanush and Kriti Sanon starrer Tere Ishk Mein has recently released. Fans and critics had high anticipation for the movie. The box office numbers are currently soaring with the movie earning more than Rs 16 crores on its first day. As per Sacnilk's early estimates, it earned around Rs 16.50 crores India net on its first day for all languages.          Interestingly, Tere Ishk Mein had an overall 25.77% Hindi occupancy. It had an occupancy of 15.29% in the morning shows. The afternoon shows saw 21.67% occupancy. The evening shows saw 24.55% occupancy while the night shows saw an occupancy of 41.56%. The overall occupancy in Mumbai stood at 25.25%. For Delhi, the occupancy was around 26.50%. As per the occupancy chart, Bengaluru saw the maximum numbers with 32.75%.The movie had an overall occupancy of 20.84% for Tamil theatres. The occupancy for morning shows stood at 20.03% while the afternoon shows were at 22.21%. The evening shows saw an occupancy of 16.13% while the night shows stood at 24.97%. Chennai saw an occupancy of 30.25% while Kochi stood at 37.50%.It would be interesting to note if Tere Ishk Mein becomes Dhanush or Kriti's top-grossing films.          This film is directed by Anand L Rai and produced by T-Series and Colour Yellow Productions. Our reviewer gave the movie 3 stars. He wrote, "Tere Ishk Mein is a pure, unfiltered Aanand L Rai vehicle. It will move some to tears and leave others exasperated. It is a film of stirring highs and distracting inconsistencies, of performances that soar and storytelling that sometimes slips. But it never, not for a moment, plays it safe. For those who’ll surrender to its heightened romanticism, it’ll offer an emotional storm impossible to forget. For others, the same storm might feel like too much weather for one film."ALSO READ: Birthday Special: Kriti Sanon’s Sartorial Styling。    类风湿性关节炎被广泛认为是一种多因素的疾病。这意味着没有一个单一的基因或环境暴露是对其发展的唯一责任。相反，可能需要一系列的因素来触发与该疾病相关的自身免疫行为。越来越多的证据表明，肠道微生物组在该疾病的发生中起着作用。事实上，一种特定的细菌菌株已经成为近年来许多研究的焦点。Prevotella copri通常不被认为是一种有害的肠道细菌菌株。

B | 它可以在大多数人的微生物组中找到，甚至与高纤维、低脂肪的饮食有关。但在过去十年中，一些研究发现类风湿性关节炎与Prevotella copri的异常水平之间存在关联。

C | 这项新的研究专门研究了一种免疫抗体的血液水平，这种抗体是针对Prevotella copri所表达的一种特定蛋白质而产生的。研究人员不仅对预先存在的类风湿性关节炎患者是否对这种特殊的细菌蛋白表现出过度的免疫反应感兴趣，而且他们还观察了处于疾病早期阶段的人群，以及被归类为发展该疾病高风险的群体。

D | 分析技术显示，与健康对照组相比，那些患有类风湿性关节炎的人确实显示出更高的抗体水平。但更重要的是，与对照组相比，那些处于该疾病高风险的人也显示出更高的抗体水平。而且，研究表明一种可能的因果关系，那些已经确立的类风湿关节炎患者与那些处于疾病最早阶段的人相比显示出更高的抗体水平。

E | 当然，这些证据还远不是确定的，仍然存在严重的问题。虽然针对这种细菌蛋白的免疫活动增加与类风湿性关节炎之间可能存在关联，但这并不一定意味着这种关系会推动疾病的发展。

F | 尽管如此，2017年的一项研究已经假设了这种特殊的Prevotella copri的蛋白质如何可能合理地触发自身免疫活动，导致关节炎的发生。但这仍然是令人难以置信的推测，新研究的通讯作者Jennifer Seifert说，这些发现需要做更多的工作，以更好地了解肠道细菌和类风湿性关节炎（RA）之间的任何潜在关系。Seifert说：“我们的希望是，这些发现可以帮助进一步阐明细菌共生体在有患RA风险的人和RA患者中的复杂病因作用，从而可以开发出有针对性的疗法，目的是提供更好的治疗，并最终预防该疾病。”这项新研究发表在《关节炎与风湿病学》上。